Pugh, K. R., Frost, S. J., Rothman, D. L., Hoeft, F., Del Tufo, S. N., Mason, G. F., . . . Fulbright, R. K. (2014). Glutamate and choline levels predict individual differences in reading ability in emergent readers. Journal of Neuroscience, 34(11), 4082-4089. doi: 10.1523/jneurosci.3907-13.2014
Pugh et al report correlations between levels of neurometabolites glutamate and choline (measured by magnetic resonance spectroscopy) and reading ability in children. However, the central result that they report is based on data that are not corrected for age, which ranges from 6 to 10 years, and there are other aspects of the results that are not reported in sufficient detail for proper evaluation.
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